High NF-κB and RAGE Expression in Fetal Membrane of Premature Rupture of Membrane (PROM) Subject

BACKGROUND: Premature Rupture of Membranes (PROM) is significantly linked to the infections-related maternal deaths. In inflammatory process, influencing stressor will stimulate activation Nuclear Factor Kappa B (NF-κB) and Receptor Advanced Gyclation End product (RAGE). Yet up date, expression NF-κB RAGE in pregnant women with PROM are still rarely studied. Therefore, this study aimed observe differences from non-PROM subjects.METHODS: This was a cross-sectional involving 20 subjects infections complications. Samples fetal membrane tissue were obtained put into paraffin block preparation for determination expression. The detection conducted using immunohistochemical staining observed under an upright light microscope. expressions later calculated ImageJ software. RESULTS: Both found be higher compare subjects. median 32.47±1.22 5.59±1.09, respectively (p=0.000). While 53.58±3.46, 11.64±2.49 (p=0.013).CONCLUSION: There significant difference between membranes increased can used as potential marker detect complication PROM.KEYWORDS: premature ruptures membrane, non-premature